DNMT1 and colon adenocarcinoma: miRNA-EMT gene interaction is shown in Figure 5, emphasizing a direct connection between DCAT3 and EEF1A2 with the TP53, one of the most frequent mutated gene in COAD, and also DNMT1 (methyl transferase), a frequent methylated gene in cancer, and two important transcription factors (EZH2 and E2F1).