PROCR and cutaneous mastocytosis: Even if both receptors are involved in CM pathological process, this may indicate a major role for ICAM-1 receptor, at least in initial strong binding to brain microvascular endothelial cells; however, parasites expressing PfEMP-1s with EPCR-binding domains (within DC8 cassette) non-linked to ICAM-1-binding domains have been associated with pediatric CM when evaluated by retinopathy or brain-swelling status [30].