In addition, it has been suggested recently, that predominantly those PfEMP1 proteins that contain tandem of domains biding to endothelial protein C receptor (EPCR) and ICAM-1 receptor are involved in CM pathogenesis [25,26], potentially binding through one or both receptors [12,27], though the role of EPCR in this binding is still controversial [28]. Here, PROCR is linked to cutaneous mastocytosis.