Nevertheless, it was shown that the activation of the Src/FAK complex by TGF-β seems independent of BRAFV600E signaling and that BRAFV600E, TGF-β and the Src/FAK complex may act cooperatively but independently in the regulation of EMT induction and cell motility in thyroid cancer [51] (Figure 2). This evidence concerns the gene PTK2 and thyroid cancer.