In this analysis from NOMED-AF, our principal findings are as follows: (i) The main risk factors for SAF were age, male gender, prior ICS/TIA, diabetes, heart failure, CKD, and NT-proBNP > 125 ng/mL; and (ii) a simple clinical risk scale (MR-DASH score) was developed, which had a good level of prediction in the derivation cohort (AUC 0.726) and the validation cohort (AUC 0.730). The gene discussed is NPPB; the disease is atrial fibrillation.