SH2 domain mutations of STAT3 (e.g., Y640F, D661Y) and STAT5B (e.g. N642H, Y665F/H) are found in mature T-cell and NK-cell neoplasms (see Table 1 for details of cancer subtypes), T-ALL, diffuse large B-cell lymphoma (DLBCL) and myeloid diseases (eosinophila, AML, chronic neutrophilic leukemia) [59,60,61,62]. Here, STAT5B is linked to diffuse large B-cell lymphoma.