Therefore, based on the above results, we studied the genes related to NOX1, and found 9 genes (NFE2L3, TSPAN6, PGRMC1, PLCB4, OCRL, CTPS2, XKRX, CFTR, ST6GAL1, NOX1) that were positively associated with NOX1. Then, two subgroups of colon cancer were identified on the basis of the expression of these genes, which were also significantly correlated with survival. The gene discussed is TSPAN6; the disease is colonic neoplasm.