Therefore, based on the above results, we studied the genes related to NOX1, and found 9 genes (NFE2L3, TSPAN6, PGRMC1, PLCB4, OCRL, CTPS2, XKRX, CFTR, ST6GAL1, NOX1) that were positively associated with NOX1. Then, two subgroups of colon cancer were identified on the basis of the expression of these genes, which were also significantly correlated with survival. This evidence concerns the gene TSPAN6 and malignant colon neoplasm.