A univariate Cox regression model revealed 60 ferroptosis-related genes’ prognostic values in patients with colon cancer, in which fifteen genes (ABCC1, ACACA, CISD1, CRYAB, CS, FANCD2, FDFT1, GLS2, GSS, HMGCR, KEAP1, LPCAT3, NFS1, NOX1, PEBP1) were associated with prognosis (Figure 1A). This evidence concerns the gene CISD1 and malignant colon neoplasm.