RUNX1 and leukemia: Translocations are frequently present in pediatric ALL including the ETV6-RUNX1 (t(12;21)(p13;q22)) chromosomal translocation [123], KMT2A translocations (t(4;11)(q21;q23)) for infant and therapy-related leukemia [175], and other translocations or deletions frequently involving chromosomes 1, 4, 6–9, 11, 12, 14, 19, 21, and 22 [122].