Our results show that the expression of ERRα metabolic target genes involved in OXPHOS, the TCA cycle, and enzymes important for detoxification are increased in obesity (basal-like breast tumours of overweight/obese versus lean patients), which aligns with our in vitro findings that exogenous cholesterol enhances the above-mentioned enzyme levels in TNBC cells. The gene discussed is ESRRA; the disease is obesity due to melanocortin 4 receptor deficiency.