The discrepant expression levels of G6PD and GART between TNBC-PDX cells treated with cholesterol and overweight/obese basal-like breast cancer patients are possibly due to multiple factors, as obesity is a complex disease, with upregulation of several growth factors and activation of other signaling pathways, such as the PI3K/Akt/mTOR pathways [70,71]. The gene discussed is GART; the disease is obesity due to melanocortin 4 receptor deficiency.