The cholesterol-induced and ERRα-dependent increase in the expression of 6PGD, a third enzyme of the PPP involved in NADPH synthesis [40], although a surprising finding, could be an adaptive response to maintain NADPH homeostasis in breast cancer cells, as NADPH is utilized for rapid tumour growth and survival under excessive oxidative stress conditions [40]. The gene discussed is ESRRA; the disease is neoplasm.