One study attempted to compare the location of [18F]-FAZA-PET with immunohistochemical staining of hypoxia markers hypoxia inducible factor-1α (HIF-1α) and carbon anhydrase XI (CAXI) to validate [18F]-FAZA-PET as a useful hypoxia identification tool in prostate cancer patients [39]. This evidence concerns the gene HIF1A and Familial prostate cancer.