We initially examined TNFα signaling in response to exogenous TNFα in 40 melanoma cell lines, including 31 cutaneous (11 BRAF-mutant, 10 NRAS-mutant, 10 BRAF/RAS WT) and nine uveal melanoma cell lines (five GNAQ-mutant, three GNA11-mutant and one GNAQ/GNA11 WT). The gene discussed is TNF; the disease is uveal melanoma.