Our investigation of the effects of exogenous TNFα on a panel of 40 melanoma cell lines with different genotypes (i.e., BRAF-mutant, NRAS-mutant and BRAF/RAS wildtype), subtypes (i.e., cutaneous and uveal) and differentiation states (i.e., neural crest-like dedifferentiated, melanocytic and transitory) revealed that the TNFα signaling pathway is maintained in all melanomas. This evidence concerns the gene NRAS and melanoma.