By changing the constitution of extracellular matrix, heparanase promotes (i) cancer metastasis by assisting cancer cell migration and invasion and (ii) angiogenesis by releasing heparin-binding cytokines including hepatocyte growth factor (HGF), vascular endothelial growth factor (VEGF), and basic fibroblast growth factor (bFGF). This evidence concerns the gene HPSE and cancer.