Although we do not include in vivo experiments, testing HDAC6 knock-down in mouse experiments in future studies is important, e.g., using mouse models of glioblastoma as those recently reviewed by Noorani [73], who discusses on more faithful mouse models resembling human gliomas, including new cre/LoxP transgenic lines that allow more accurate cell targeting of genetic recombination, Sleeping Beauty [74], and PiggyBac transposons [68] for the integration of transgenes and genetic screens and CRISPR-cas9 [75] for generating genetic knockout and functional screens. This evidence concerns the gene HDAC6 and central nervous system cancer.