CYCS and cancer: It is possible that cyclooxygenase (COX) overexpression observed in cancers [45,46] is related to disruption in the process of electron transfer from cytochrome c. Detailed analysis will be necessary to find correlation between conformations and other alterations in COX subunits and electron transfer from cytochrome c. Since COX inhibitors belong to the most commonly taken drugs [47,48], further research should focus on understanding the mechanisms of correlation.