The EBV immediately early (IE) proteins BZLF1 and BRLF1 promote interleukin-6 (IL-6) secretion in lytically infected cells, sustaining early lymphoproliferative disease [11] as IL-6 (a cytokine playing a key role in maintenance of immune functions, stimulation of hematopoietic cells differentiation and persistence of inflammation) is a decisive element in various epithelial and hematological malignancies. This evidence concerns the gene IL6 and hematologic disorder.