RELA and familial pancreatic carcinoma: In line with our study, upregulation of HIF-1α under hypoxic conditions heightened NF-κB signaling, which was demonstrated by the increased binding activity of NF-kB p65 proteins and NF-κB DNA after initiation of hypoxia, and inhibition of NF-κB was associated with the suppression of hypoxia-induced migration in pancreatic cancer cells [42].