There is evidence that Satb1 and Satb2 can affect intracellular signaling of neurons via chromatin looping of the NMDA receptor locus GRIN2B46 [58] and two schizophrenia-risk genes encoding the GABA synthesis enzyme (GAD1) and the calcium channel alpha subunit CACNA1C in the activation of cognitive and physical disturbances [59,60]. This evidence concerns the gene GAD1 and schizophrenia.