Binary logistic analysis of these significant risk variables showed that BMI (95%CI: 1.45–2.74), TG (95%CI: 1.31–2.98), poor sleep (95%CI: 1.72–3.09), IL-6 (95%CI: 1.62–3.01), IL-1β (95%CI: 1.07–2.67), and CRP (95%CI: 1.15–3.75) were independent predictors for osteoarthritis risk, whereas, SBP, DBP, TC, and TNF-α did not influence the risk of osteoarthritis. This evidence concerns the gene IL6 and osteoarthritis.