AGT was observed to have a strong association with the risk of osteoarthritis (OR 3.12, 95%CI: 1.88–5.19), which remained significant even after additional adjustment with BMI, TG, sleep, IL-6, IL-1β, and CRP levels (OR 2.73, 95%CI:1.63–4.72). This evidence concerns the gene CRP and osteoarthritis.