Other SNP pairs that showed two-way epistatic relationships were rs1800797-rs18008593, rs1800796-rs1107946, rs12700386-rs1800947, rs2794521-rs1544410, rs891512-rs2070744, and rs2228570-rs1800012, impacting IL-1β (p = 0.0035), TG (p = 0.0055), hsCRP (p = 0.0036), TG (p = 0.0014), BMI (p = 0.0028), and sleep (p = 0.0063) through AD, DA, DD, I, and AA modes, respectively. The gene discussed is IL1B; the disease is Alzheimer disease.