Univariate regression analysis of risk variables (Table 2) revealed that BMI (95%CI: 1.64–2.92), LDL (95%CI: 1.37–2.75), TG (95%CI: 1.45–3.15), poor sleep (95%CI: 1.88–3.62), IL-6 (95%CI: 1.73–3.16), IL-1β (95%CI: 1.12–2.83), and hsCRP (95%CI: 1.23–4.16) were significant variables for the risk of osteoarthritis. The gene discussed is IL6; the disease is osteoarthritis.