VWF and COVID-19: Regarding viral transmission, it has been shown that EVs from patients infected with COVID-19 transfer to target cells prothrombotic and endothelial injury factors such as TF, t-PA, vWF, proteins associated with cardiovascular pathology (MB, PRSS8, REN, HGF), cytokines (TNF-α, IL-6), chemokines (MCP-1, CXCL16), proteases and peptidases including cathepsin L1, an enzyme involved in tissue remodelling [152].