CD28 and neoplasm: For this purpose, Chiang et al. reported the used of superparamagnetic iron oxide nanoparticles conjugated with anti-PD-L1 and anti-CD3/anti-CD28 to enhance tumour-targeted delivery via magnetic navigation by means of an external magnetic field of 0.22 T applied to the tumour site of 4T1 tumour-bearing mice (as described in detail in Section 8.1).