For instance, it was reported that a naphthalene diimide derivative was able to inhibit the growth of gastrointestinal stromal tumor cells (GIST) as a consequence of its ability to interact with the G4 located both at the telomeric level and in the promoter region of the KIT [17], an oncogene that is constitutively activated in GIST and it is responsible for the acquired resistance to clinically relevant tyrosine kinase inhibitors (e.g., Imatinib) [73]. This evidence concerns the gene KIT and gastrointestinal stromal tumor.