BCL2 and neoplasm: For instance, it was formerly reported that the tetra-substituted naphthalene-diimide derivative MM41 strongly binds the G4 within the promoters of both BCL-2 and KRAS [17,70] and exerts a remarkable anti-tumor activity, with some evidence of no tumor re-growth observed after >200 days post-treatment, in a pancreatic cancer xenograft models [70].