Therefore, nine derivatives were generated and it was found that one of the 10-(4-acetamidobenzylidene)-9-anthrone (DK-V-47, Figure 8) derivatives was more effective than emodin at suppressing p185neu tyrosine phosphorylation and preventing HER-2/neu-overexpressing human breast cancer cells’ proliferation and modification. The gene discussed is ERBB2; the disease is breast carcinoma.