NFKB1 and colonic neoplasm: Negatively regulated NF-κβ, PI3K/AKT, MAPK/JNK, and STAT pathways and inhibited MMP-7, MMP-9, and VEGF proteins are found to be key markers of the emodin.Like other cancer cell lines, emodin caused mitochondrial dysfunction and decreased mitochondrial membrane potential in colon cancer cell lines.