As a result of the examination of the tumor microenvironment, decreased inflammatory cell (CD11b+ and F4/80+) uptake, decreased expression of cytokines (IL1α/β, IL6, CCL2, CXCL5, and TNFα) and pro-inflammatory enzymes (COX-2, and NOS2) were determined [143]. The gene discussed is NOS2; the disease is neoplasm.