Gingipain-related ECM degradation is, however, not limited to fibrous components, as these proteases, in conjunction with the receptor activator of nuclear factor kappa-B ligand (RANK-L), promote osteoclastogenesis, which is a prerequisite for the destruction of the mineral matrix during alveolar bone resorption in periodontitis [261]. The gene discussed is TNFSF11; the disease is periodontitis.