This is associated with an enhanced secretion of inflammatory mediators such as CXC chemokines, including CXCL-9 (MIG), CXCL-10 (IP-10) and CXCL-11 (I-TAC/IP9), which are known to play a pivotal role in SSc pathogenesis [11,12,13,14,15]. Here, CXCL10 is linked to systemic sclerosis.