Some of the top pathways identified in our screen are associated with focal adhesion, RNA transport, tight junction related pathways, spliceosome, ECM-receptor interaction, and PI3K-AKT signaling pathways, etc. Interestingly, multiple groups have reported a strong correlation between the PI3K pathway, which is essential for various cellular functions (such as endothelial cell sprouting for angiogenesis, T cell differentiation and homeostasis, fibroblast associated resistance, and macrophage transcriptional reprogramming [43,44,45,46]) and pancreatic cancer. This evidence concerns the gene AKT1 and familial pancreatic carcinoma.