NR1H4 and Hepatic fibrosis: The differentially expressed proteins in response to BDE-47 in the testes were significantly enriched in the following pathways, which are related to male reproductive toxicity: Hepatic fibrosis/hepatic stellate cell activation, the GP6 signaling pathway, tight junction signaling, acute phase response signaling, LXR/RXR activation, unfolded protein response, and FXR/RXR activation (Figure 4A).