CCN2 and breast cancer: In breast cancer cells, miR-124 expression can suppress metastasis by targeting and regulating genes that contribute to cytoskeletal dynamics, such as connective tissue growth factor (CTGF), ras homolog family member G (RHOG), integrin beta-1 (ITGB1), and rho-associated coiled-coil-containing protein kinase (ROCK1) [89].