Di Salvo et al. reported that the top 10 differential expressed genes (DEGs) exhibited high sensitivities, specificities and predictive values included SERPINA3, SERPINA5, LCN6, LCN10, STEAP4, AKR1C1, STAC2, SPARCL1, VSIG4, and F8. Among them, STEAP4, SPARCL1, VSIG4 were differentially expressed in HF involving the RV versus HF involving the left ventricle (LV). The gene discussed is F8; the disease is hydrops fetalis.