Several studies have established that Tau phosphorylates GSK3 at multiple disease-relevant sites in mouse models of AD and in the patient brains, and is a central kinase in Tau hyperphosphorylation causing disassociation of Tau from microtubules and fibrillization [15,158,159,160,161] (Figure 1A). The gene discussed is MAPT; the disease is Alzheimer disease.