ADGRL3 and head and neck squamous cell carcinoma: By retrieving gene expression from 11 HNSCC studies, Locati et al. characterized three distinct HPV(+) subtypes, defined as Cl1 (immune-related), Cl2 (highly keratinized, epithelial mesenchymal transition-related and hypoxia), and Cl3 (highly keratinized, proliferation-related) [23].