To investigate whether HDAC8 is correlated with therapy-resistant GBM, we examined the HDAC8 expression level of two parent GBM cell lines (A172 and U87MG, wild-type p53 (WT-p53), Supplementary Table S1) and two TMZ-resistant GBM cell lines (A172-R and U87MG-R, variants of WT-p53). The gene discussed is HDAC8; the disease is glioblastoma.