miRNAs can regulate the expression of numerous enzymes that participate in glucose uptake, including glycolytic enzymes such as HK2, controlled by miR-143, miR-145 and miR-155 in BC [168,169,170]; PKM2 regulated by miR-326 and miR133a/b [21]; or the expression of LDHA, which is controlled by miRNAs such as miR-34a or miR-200c in urothelial tumors, favoring the production of lactate [167,171], among others. The gene discussed is PKM; the disease is breast cancer.