As mentioned above, EZH2 promotes global changes in gene and ncRNA expression, can cooperate with other chromatin remodelers or may co-occupy several gene loci with G9A in order to maintain gene silencing in a cooperative and coordinated manner, which has been shown in BC [116] and could explain some oncological properties of EZH2 that could favor heterogeneity in tumors [117]. This evidence concerns the gene EHMT2 and breast cancer.