SIRT1 is mainly involved in tumor suppressor in cancer, including BC [140,152,153]; it can suppress glycolysis indirectly through the deacetylation of HIF, which in turn can regulate the transcription of various glycolytic enzymes such as LDH, G6P, PFK-1, PGK-1, PGAM-1 or transporters such as GLUT1 or GLUT3 [154,155]. The gene discussed is SLC2A1; the disease is neoplasm.