SDHB and paraganglioma: Patients with an SDHD mutation are also commonly predisposed to CBTs (solitary or those with multiplicity) [11], thus supporting our findings of three tumors in two patients with SDHD. On the other hand, the SDHB mutation c.287G > A (p.Gly96Asp) in patient no. 4 was reported in patients with malignant catecholamine-producing paragangliomas [33] as well as in two pediatric patients with functional tumors [34].