DLAT and primary biliary cholangitis: In contrast with these proteins mentioned above that were not previously described as the target of aAbs, DLAT (E2 component of pyruvate dehydrogenase complex) has been previously reported as an aAb in patients with liver disease, in particular in primary biliary cirrhosis which manifest with inflammatory obliteration of intra-hepatic bile duct, leading to liver cell damage and cirrhosis [28].