The clinical presentation of the resulting multisystem inflammatory syndrome in children (MIS-C) reflects that of Kawasaki, but differences between the two exist with regards to age (from early childhood to late adolescence as compared to early childhood in Kawasaki); more frequent lymphopenia and thrombocytopenia, cardiac ventricular stress including myocarditis, and coagulopathy in MIS-C, more frequent gastrointestinal involvement, myocarditis leading to cardiogenic shock, and a different cytokine profile (IL-6 and IL-8 in MIS-C, IL-1 in Kawasaki). This evidence concerns the gene CXCL8 and myocarditis.