TNF and psoriasis: Moreover, some plants, including Datura Metel L. mustard seed and rosmarinic acid (RA), play a protective role against the development of imiquimod-induced psoriasis by inhibiting NLRP3 inflammasome activation [8,26] by cytokines, such as IL-1β, IL-6, IL-8, CCL20, and TNF suppression.