Undoubtedly, the pro-inflammatory cytokine IL-1β plays a crucial role in the pathogenesis of many inflammatory diseases of the human skin, including psoriasis, but the keratinocytes of murine models, with many studies, do not express IL-1β, only cytokine IL-18, which can be cleaved to its active form by inflammasomes in these cells [47]. This evidence concerns the gene IL18 and psoriasis.