Although, IL-17, IL-23, and tumor necrosis factor (TNF) are recognized as main cytokines involved in the development of psoriasis, more attention is paid to the role of the activation of the multi-protein inflammasome complex in the pathogenesis of psoriasis, which in turn is associated with increased production of IL-1β and IL-18 [8,9,10]. This evidence concerns the gene IL1B and psoriasis.