In one such study, Drago et al. [53] showed that propolis augmented apoptosis of butyrate-sensitive colon cancer cells (HCT116 cell line) and re-sensitized butyrate-resistant colon cancer cells to apoptosis was possible by suppressing AKT signaling and downregulating the JAK/STAT pathway. The gene discussed is AKT1; the disease is colonic neoplasm.