In prostate cancer, knocking out PTPN11 (NK cell inhibitory receptor) in CAR-expressing NK-YT cells directed against PSMA (PSMA-directed.CD8α.CD28.CD3ζ.CAR-NK-YT) resulted in increased cytotoxicity against the Du-145 cell line, which is naturally resistant to NK cell killing [118]. This evidence concerns the gene CD247 and Familial prostate cancer.