To add more, EBV + DLBCL also promotes an exhausted immune microenvironment, by the dysregulation of immune checkpoint PD1/PDL1, LAG3, and TIM3 [54,97], the shift to a higher pro-tumoral CD163/CD68 “M2” macrophage polarization pattern [97] or the increase of immunosuppressive cytokine IL10 [68]. Here, LAG3 is linked to diffuse large B-cell lymphoma.