Kiyasu et al. discriminated PDL1 expression in tumor cells and at the microenvironment, and described that PDL1 + cells at the TME was significantly associated with EBV positivity, whereas, unexpectedly, the number of the PD1+ tumor infiltrating lymphocytes, the ligand of PDL1, was not related to EBV presence [90]. The gene discussed is CD274; the disease is neoplasm.