In EBV + DLBCL, immediate-early BZLF1, early BHRF1 and BMRF1, late BLLF1 lytic viral genes expression was detected, and their expression was correlated with IL10 and IFNγ expression, revealing a link between viral lytic cycle and EBV + DLBCL pathogenesis [55]. This evidence concerns the gene IFNG and diffuse large B-cell lymphoma.