The immune regulatory environment observed in EBV + DLBCL also involves increased gene expression of immunosuppressive cytokine IL10 [68], which could be triggered directly by LMP1 [93], and/or lytic antigens [55], or, alternatively, by the presence of regulatory T cells that secrete IL10, as observed in EBV-associated HL, nasopharyngeal and gastric carcinomas, and in EBV-transformed B cell lines [84,94]. The gene discussed is IL10; the disease is diffuse large B-cell lymphoma.