TP53 and cancer: According to the KEGG, the strongly associated pathways with the TTK, NEK2, and CDK1 network involved the cell cycle, leukocyte transendothelial migration, biosynthesis of amino acids, p53 signaling pathway, cellular senescence, cell adhesion molecules (CAMs), viral carcinogenesis, hepatitis C, tight junctions, pathways in cancer, small cell lung cancer, and oocyte meiosis (Figure 2B) (Supplementary Material Table S3).