For example, expression of functional IL-17 receptors on pancreatic intraepithelial neoplasia (PanIN) induced by KrasG12D and infiltration of the pancreatic stroma by IL-17-producing immune cells induce stem cells features of PanIN and pancreatic cancer cells and accelerate PanIN initiation and progression to invasive tumor [94,95]. This evidence concerns the gene IL17A and pancreatic neoplasm.