For example, the status of tumor differentiation, severity of desmoplastic reaction, levels of VDR and CYP24A1 expression, and the status of p53 mutation and VDR SNPs should also be considered in the experimental design and data interpretation, since these factors were reported to affect vitamin D/VDR signaling and treatment response [19,74,81,84,89,90]. This evidence concerns the gene TP53 and neoplasm.