BRCA1 and breast carcinoma: Her father was diagnosed with colon cancer at 74 years old and her paternal grandmother died of uterus cancer at 80 years old; (b) AN519 is a 26-year-old woman, bearing three pathogenic variants coexisting in exon 5 of BRCA1, one of which is the recurrent variant of Spanish origin c.211del, p.(Arg71Glyfs*17) and the other two are c.187_188del, p.(Leu63Metfs*2), and c.191G>A, p.(Cys64Tyr) with a personal history of metachronic bilateral breast carcinoma, TN in right breast to follow at the age of 38 years with a ductal infiltrating carcinoma in the contralateral breast.