Here, we reported the relationships between oral cancer and MACC1 SNPs, people who had rs4721888 variants may have more susceptibility to oral cancer whether they were used to betel quid chewing or not, and the oral cancer patients who had the habit of betel quid chewing and rs975263 variants would have more potential risk of lymph node metastasis. Here, MACC1 is linked to metastatic malignant neoplasm in the lymph nodes.