The expression of phosphoglucomutase-2-like 1 (PGM2L1) and phosphoglycerate kinase (PGK), two key enzymes in glycolysis, is downregulated in fibroblasts from sporadic ALS patients, which may lead to the reduction in the ability to catabolize carbohydrates in human ALS patients [138]. Here, PGM2L1 is linked to amyotrophic lateral sclerosis.