HLA-DRB1 and cancer: An HLA-DRB1 CUG.1 > CUA variant and an AUG.1 > AUA/GUG.1 > AUG were both detected in multiple types of cancer and also caused significant but somewhat less pronounced reductions of relative luciferase signals (0.39 ± 0.03, p < 0.01 and 0.19 ± 0.01, p < 0.01, respectively) as compared to the ΔCUG.6 variant (Figure 3b,c).