As shown in Figure 7A,B, only GSK-2606414 and ISRIB could suppress sorafenib-induced ZFAS1 expression in PLC5 cells, suggesting that the PERK/ATF4 arm of UPR is responsible for the upregulation of ZFAS1 by sorafenib in sorafenib-resistant HCC cells. The gene discussed is ATF4; the disease is hepatocellular carcinoma.