TP53 and systemic lupus erythematosus: To this end, transcriptomic analysis in several B subsets (rN: resting naïve, T3: transitional 3, aN: activated naïve, SM: isotype-switched memory and DN2: double negative) from SLE patients compared to healthy controls identified deregulated DDR pathways, such as the p53 signaling being positively enriched in all of the SLE B cells and the G2/M cell cycle checkpoint being upregulated in all of the subsets, except for DN2 B cells where it was downregulated [69].