Anti-p53 antibodies that block p53, a crucial DDR effector molecule that regulates DNA repair and cell cycle arrest, and other autoantibodies related to DNA repair components (APEX1, AURKA, POLB, AGO1, HMGB1, IFIT5, MAPKAPK3, PADI4, RGS3, SRP19, UBE2S and VRK1) have been found in the serum of SLE patients [48,49]. This evidence concerns the gene POLB and systemic lupus erythematosus.