CD4 and colitis: Of note, the T cell response to the colitis process was totally blunted in the treated group, an effect evidenced across different T cell subpopulations, such as cytotoxic CD8+ T cells, Th1 (CD4+IFNg+), Th2 (CD4+IL4+), Th17 (CD4+IL17+), and Tregs (CD4+FoxP3+).