AXIN2 and colorectal carcinoma: In the case of colorectal carcinoma, instead of acting as a tumor suppressor from a functional point of view, AXIN2 promotes the progression of the disease by promoting the epithelial–mesenchymal transition through the upregulation of SNAIL1 [26], and the overexpression of AXIN2 enhances the invasiveness of the colon carcinoma.