The heparan sulfate proteoglycan belonging to the Syndecans family is largely involved in the onset of different CVD in vasculature, and in particular is reported to be increased in patients with resistant hypertension [21], while syndecan-3/-4 ectodomain fragments, produced by several stimuli, including heparinase or thrombin, decrease endothelial cell–cell adhesive barrier integrity [23] and are involved in the cell-extracellular matrix and cell–cell adhesion mechanisms [22]. Here, SDC3 is linked to Hypertension resistant to conventional therapy.