SDC1 and cancer: Syndecans are a family of four transmembrane HSPGs that are expressed in a cell-type-specific manner [11]; Syndecan-1 is present during development and in adult endothelium and cancer cells; Syndecan-2 is expressed in liver, mesenchymal tissue, and neuronal cells; Syndecan-3 is a neuronal type; and Syndecan-4 is ubiquitously distributed [12,13].