PHOX2B and neuroblastoma: In the whole-genome sequencing analysis of neuroblastoma, recurrent genomic rearrangements of the catalytic subunit of TERT (5p15.33) and of the alpha thalassemia/mental retardation syndrome X-linked (ATRX) genes have been identified [127], in addition to MYCN amplifications, ALK, and PHOX2B. A subgroup of HR-NB tumors is characterized by the active ALT mechanism, whose function is negatively regulated by the ATRX gene [130].